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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXT1
All Species:
21.82
Human Site:
Y469
Identified Species:
40
UniProt:
Q16394
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16394
NP_000118.2
746
86255
Y469
L
G
D
F
P
Y
Y
Y
A
N
L
G
L
K
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108202
675
74245
R413
Y
H
L
Q
Q
G
S
R
P
E
G
R
F
S
A
Dog
Lupus familis
XP_539145
746
86191
Y469
L
G
D
F
P
Y
Y
Y
A
N
L
G
L
K
P
Cat
Felis silvestris
Mouse
Mus musculus
P97464
746
86289
Y469
L
G
D
F
P
Y
Y
Y
A
N
L
G
L
K
P
Rat
Rattus norvegicus
NP_001101455
670
74649
S408
Y
H
L
Q
L
G
S
S
P
G
S
S
F
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509292
443
50957
I181
P
S
K
F
T
A
V
I
H
A
V
T
P
L
V
Chicken
Gallus gallus
XP_418396
865
98072
Y588
L
G
D
F
P
Y
Y
Y
A
N
L
G
L
K
P
Frog
Xenopus laevis
NP_001083782
738
84810
Y461
L
G
D
F
P
Y
Y
Y
S
N
L
G
A
K
P
Zebra Danio
Brachydanio rerio
Q5IGR7
741
85103
Y464
L
G
D
L
P
F
F
Y
A
K
L
G
I
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V730
760
87290
L466
S
R
Y
M
P
F
L
L
N
S
M
G
A
E
P
Honey Bee
Apis mellifera
XP_391845
711
82974
P446
L
P
F
S
K
S
N
P
G
N
T
F
T
A
I
Nematode Worm
Caenorhab. elegans
O01704
378
44434
W116
E
S
L
D
P
S
V
W
N
N
G
R
N
H
L
Sea Urchin
Strong. purpuratus
XP_783281
693
79753
L431
P
S
N
K
F
S
A
L
V
L
V
Q
T
P
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
43.9
99.1
N.A.
99.3
42.3
N.A.
58
78.2
88.4
83.6
N.A.
54.4
55.6
26.2
52.1
Protein Similarity:
100
N.A.
60.4
99.5
N.A.
99.7
58.7
N.A.
58.9
81
94.2
91.9
N.A.
69.8
70.2
37.4
68.2
P-Site Identity:
100
N.A.
0
100
N.A.
100
0
N.A.
6.6
100
86.6
66.6
N.A.
20
13.3
13.3
6.6
P-Site Similarity:
100
N.A.
0
100
N.A.
100
0
N.A.
13.3
100
93.3
86.6
N.A.
46.6
13.3
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
8
0
39
8
0
0
16
8
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
47
8
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% E
% Phe:
0
0
8
47
8
16
8
0
0
0
0
8
16
0
0
% F
% Gly:
0
47
0
0
0
16
0
0
8
8
16
54
0
0
0
% G
% His:
0
16
0
0
0
0
0
0
8
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
8
% I
% Lys:
0
0
8
8
8
0
0
0
0
8
0
0
0
47
0
% K
% Leu:
54
0
24
8
8
0
8
16
0
8
47
0
31
8
8
% L
% Met:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
8
0
16
54
0
0
8
0
0
% N
% Pro:
16
8
0
0
62
0
0
8
16
0
0
0
8
8
62
% P
% Gln:
0
0
0
16
8
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
8
0
0
0
16
0
0
0
% R
% Ser:
8
24
0
8
0
24
16
8
8
8
8
8
0
16
0
% S
% Thr:
0
0
0
0
8
0
0
0
0
0
8
8
16
0
0
% T
% Val:
0
0
0
0
0
0
16
0
8
0
16
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
16
0
8
0
0
39
39
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _